Stadium: Manning Field at John L. Guidry Stadium Round: 1
Home Manager: Tim Rebowe Away Manager: Bob Nielson
| NCAAF | 2017/11/18 20:00 | South Dakota v South Dakota State | L | 28-31 |
| NCAAF | 2017/11/11 20:30 | North Dakota State v South Dakota | L | 49-14 |
| NCAAF | 2017/11/04 18:00 | Northern Iowa v South Dakota | L | 34-29 |
| NCAAF | 2017/10/28 20:00 | South Dakota v SO Illinois | W | 42-0 |
| NCAAF | 2017/10/21 19:00 | Illinois State v South Dakota | L | 37-21 |
| NCAAF | 2017/10/14 19:00 | South Dakota v Indiana State | W | 56-6 |
| NCAAF | 2017/10/07 19:00 | South Dakota v Youngstown State | W | 31-28 |
| NCAAF | 2017/09/30 20:00 | Western Illinois v South Dakota | W | 33-38 |
| NCAAF | 2017/11/17 00:00 | SE Louisiana v Nicholls State | L | 21-17 |
| NCAAF | 2017/11/11 21:00 | Stephen F. Austin v Nicholls State | W | 13-34 |
| NCAAF | 2017/11/04 20:30 | Nicholls State v Houston Christian | W | 23-17 |
| NCAAF | 2017/10/28 19:00 | Incarnate Word v Nicholls State | W | 31-38 |
| NCAAF | 2017/10/14 20:00 | Nicholls State v Abilene Christian | W | 29-20 |
| NCAAF | 2017/10/07 16:00 | Nicholls State v Northwestern State | W | 14-10 |
| NCAAF | 2017/10/01 00:00 | Lamar v Nicholls State | W | 14-41 |
| NCAAF | 2017/09/23 23:00 | Sam Houston State v Nicholls State | L | 66-17 |