Stadium: Bragg Memorial Stadium Round: 1
Home Manager: Willie Simmons Away Manager: Eric Dooley
| NCAAF | 2021/11/06 23:00 | Florida A&M v Southern | L | 29-17 |
| NCAAF | 2019/09/21 22:00 | Southern v Florida A&M | L | 21-27 |
| NCAAF | 2022/10/29 18:00 | Southern v Jackson State | L | 0-35 |
| NCAAF | 2022/10/22 21:00 | Southern v Lynchburg Dragons | W | 51-7 |
| NCAAF | 2022/10/15 23:00 | Alcorn State v Southern | W | 17-21 |
| NCAAF | 2022/10/08 21:00 | Southern v Prairie View | W | 45-13 |
| NCAAF | 2022/10/01 23:00 | Arkansas Pine Bluff v Southern | W | 3-59 |
| NCAAF | 2022/09/17 21:00 | Southern v Texas Southern Tigers | L | 0-24 |
| NCAAF | 2022/09/10 23:30 | Southern v LSU | L | 17-65 |
| NCAAF | 2022/09/03 23:00 | Southern v Florida Memorial University Lions | W | 86-0 |
| NCAAF | 2022/10/29 20:00 | Arkansas Pine Bluff v Florida A&M | W | 6-27 |
| NCAAF | 2022/10/15 18:00 | Florida A&M v Grambling State | W | 20-16 |
| NCAAF | 2022/10/08 18:00 | Florida A&M v South Carolina State | W | 20-14 |
| NCAAF | 2022/10/01 22:00 | Mississippi Valley State v Florida A&M | W | 7-34 |
| NCAAF | 2022/09/24 22:00 | Alabama v Florida A&M | W | 25-38 |
| NCAAF | 2022/09/10 22:00 | Florida A&M v Albany State Golden Rams | W | 23-13 |
| NCAAF | 2022/09/04 19:00 | Florida A&M v Jackson State | L | 3-59 |
| NCAAF | 2022/08/28 00:15 | Florida A&M v North Carolina | L | 24-56 |