Stadium: Alamodome Round: 1
Home Manager: Jeff Traylor Away Manager: Clarence McKinney
| NCAAF | 2022/09/17 21:00 | Southern v Texas Southern Tigers | W | 0-24 |
| NCAAF | 2022/09/10 23:30 | Texas Southern Tigers v North Texas | L | 27-59 |
| NCAAF | 2022/09/03 23:00 | Texas Southern Tigers v Prairie View | L | 23-40 |
| NCAAF | 2021/11/20 20:00 | Texas Southern Tigers v Alabama State | L | 21-24 |
| NCAAF | 2021/11/13 20:00 | Alabama v Texas Southern Tigers | L | 52-49 |
| NCAAF | 2021/11/06 18:00 | Texas Southern Tigers v Jackson State | L | 21-41 |
| NCAAF | 2021/10/30 19:00 | Arkansas Pine Bluff v Texas Southern Tigers | W | 17-59 |
| NCAAF | 2021/10/24 00:00 | Alcorn State v Texas Southern Tigers | L | 44-27 |
| NCAAF | 2022/09/18 00:00 | Texas-San Antonio v Texas | L | 20-41 |
| NCAAF | 2022/09/10 16:00 | Texas-San Antonio v Army | W | 41-38 |
| NCAAF | 2022/09/03 19:30 | Houston v Texas-San Antonio | L | 37-35 |
| NCAAF - Bowl Games | 2021/12/22 00:30 | San Diego State v Texas-San Antonio | L | 38-24 |
| NCAAF | 2021/12/04 00:00 | Western Kentucky v Texas-San Antonio | W | 41-49 |
| NCAAF | 2021/11/27 19:00 | Texas-San Antonio v North Texas | L | 23-45 |
| NCAAF | 2021/11/20 20:30 | UAB v Texas-San Antonio | W | 31-34 |
| NCAAF | 2021/11/13 20:30 | Southern Mississippi v Texas-San Antonio | W | 17-27 |