Stadium: Alerus Center Round: 1
Home Manager: Bubba Schweigert Away Manager: Brock Spack
| NCAAF | 2021/11/06 17:00 | Northern Iowa v Illinois State | W | 10-17 |
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | L | 31-38 |
| NCAAF | 2021/10/23 18:00 | Illinois State v South Dakota | W | 20-14 |
| NCAAF | 2021/10/16 19:00 | North Dakota State v Illinois State | L | 20-0 |
| NCAAF | 2021/10/02 18:00 | Missouri St v Illinois State | L | 41-20 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | L | 17-35 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | W | 31-24 |
| NCAAF | 2021/09/11 21:00 | Illinois State v Western Michigan | L | 0-28 |
| NCAAF | 2021/11/06 17:00 | Youngstown State v North Dakota | W | 21-24 |
| NCAAF | 2021/10/30 19:00 | North Dakota v Missouri St | L | 28-32 |
| NCAAF | 2021/10/23 19:00 | Western Illinois v North Dakota | W | 10-34 |
| NCAAF | 2021/10/16 19:00 | North Dakota v SO Illinois | L | 28-31 |
| NCAAF | 2021/10/09 19:00 | North Dakota v South Dakota | L | 13-20 |
| NCAAF | 2021/10/02 19:00 | North Dakota State v North Dakota | L | 16-10 |
| NCAAF | 2021/09/18 21:00 | Drake Bulldogs v North Dakota | W | 0-38 |
| NCAAF | 2021/09/11 01:00 | North Dakota v Utah State | L | 24-48 |